Molecular Replacement (Mr): Unlocking The Structure Of Macromolecules With X-Ray Crystallography
Molecular replacement (MR) is a technique used in X-ray crystallography to determine the three-dimensional structure of a macromolecule by using a known structure as a reference. MR involves searching for a candidate molecule (the search model) within the target molecule, calculating correlation coefficients between the two, and performing iterative refinements to identify the optimal orientation…